[HTML][HTML] Opioid receptor-mediated regulation of neurotransmission in the brain

KC Reeves, N Shah, B Muñoz… - Frontiers in Molecular …, 2022 - frontiersin.org
… ) and inhibitory (often GABAergic) transmission and postsynaptic … , while KORs inhibit both
GABA and glutamate transmission, … that prevents the strong feedforward inhibition of CA3-CA2 …

An endogenous opioid circuit determines state-dependent reward consumption

DC Castro, CS Oswell, ET Zhang, CE Pedersen… - Nature, 2021 - nature.com
… , we observed a sustained inhibition of GCaMP activity (lasting … be activated via retrograde
transmission. To determine whether … The cut-off was set to 10 s after immersion to prevent

Deletion of mu opioid receptors reduces palatable solution intake in a mouse model of binge eating

G Awad, LA Roeckel, D Massotte… - Behavioural …, 2020 - journals.lww.com
… Binge eating in humans is driven by hedonic properties of food, … group with restricted access
to both commodities (4SUC/4F). … food intake or seeking responses when access to palatable …

Mu-opioids suppress GABAergic synaptic transmission onto orbitofrontal cortex pyramidal neurons with subregional selectivity

BK Lau, BP Ambrose, CS Thomas, M Qiao… - Journal of …, 2020 - Soc Neuroscience
opioids to the OFC can alter the hedonic reaction to food … that mu-opioids affect inhibitory
synaptic transmission within the … that enhancing endogenous opioid levels by preventing their …

[HTML][HTML] The opioid system and food intake: use of opiate antagonists in treatment of binge eating disorder and abnormal eating behavior

LP Valbrun, V Zvonarev - Journal of clinical medicine research, 2020 - ncbi.nlm.nih.gov
… appetite, as they send a stop-food signal to the brain secreting … Both medications were able
to inhibit food intake, and some … novel µ opioid receptor antagonist, on food seeking behavior …

Cellular and behavioral basis of cannabinioid and opioid interactions: implications for opioid dependence and withdrawal

A Mohammadkhani, SL Borgland - Journal of Neuroscience …, 2022 - Wiley Online Library
… CB1 or μ opioid receptors inhibit adenylate cyclase (AC) … Both effects were dependent upon
dopamine transmission in the mPFC as systemic blockade of dopamine receptors prevented

Rebuilding the behavioral inhibition circuit to prevent opioid relapse

X Liu, T Lu, Y Han, L Lu - Neuron, 2024 - Elsevier
… The opioid system, particularly the μ-opioid receptors, … approval from the US Food and Drug
Administration for its … involvement of μ-opioid receptors in modulating transmission from PVT …

Restoration of a paraventricular thalamo-accumbal behavioral suppression circuit prevents reinstatement of heroin seeking

JE Paniccia, KM Vollmer, LM Green, RI Grant… - Neuron, 2024 - cell.com
… Finally, we find an enrichment of μ-opioid receptors in output- … may be incapable of preventing
opioid-motivated seeking. For … inhibitory effects only when heroin seeking is enhanced by …

[HTML][HTML] An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice

KM Vollmer, LM Green, RI Grant, KT Winston… - Nature …, 2022 - nature.com
µ-opioid receptors. Overall, our findings reveal a thalamostriatal feedforward inhibitory brake
for reward seekingopioid heroin prevents PVT→NAc-dependent suppression of sucrose …

[PDF][PDF] Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect

W Wang, X Xie, X Zhuang, Y Huang, T Tan, H Gangal… - Cell reports, 2023 - cell.com
opioid exposure and withdrawal potentiates GABAergic striatopallidal and striatonigral
transmission, inhibit… less than 2 ms were likely mediated by two components: ChR2induced direct …